DIRECTOR, RESEARCH LIVER METABOLICS
Duties: Reporting to the Director of the Gene Therapy Program (GTP), the Director of Research - Liver Metabolics oversees all aspects of liver metabolic research at the GTP at PENN. This role will be responsible for establishing processes for mentoring and leading SRIs in research projects. This role directly oversees and manages a team of SRIs and technicians. In consultation with the PI of the Gene Therapy Program, the Director of Research - Liver Metabolics will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for liver metabolic disorders.
GTP is a complex R&D organization consisting of research laboratories supported by multiple core functions which provide internal capacity to perform gene transfer studies from basic research through phase 1 proof-of-concept human trials. We currently employ 160 FTEs with an annual operating budget of $50M based on a wide array of funding sources. The R&D enterprise has at its core a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core and Manufacturing unit that conducts GMP-based assays and oversees CMOs in vector production, and a large non-clinical program for animal testing under GLP, including nonhuman primate and mouse vivaria; GTP collaborates with the Department of Medicine in the organization and conduct of phase 1 trials. In addition to these translational programs, GTP is involved in an ambitious vector discovery program called AAV 3.0 which is being leveraged against standard gene replacement therapy programs, as well as research in genome editing. These programs involve multiple federal, nonprofit and commercial partners.
The Director of Research will be asked to build a team of SRIs to support GTP's Liver Metabolics research effor
Qualifications: A Master's Degree and 5 years to 7 years of experience or equivalent combination of education and experience required. PhD strongly preferred.
Extensive knowledge of life science research in both academic and bio-pharmaceutical settings
Self starter but also a strong desire to contribute and work collaboratively to achieve goals
Success in roles requiring execution of multiple tasks while responding to multiple priorities
Highly functioning, detail-oriented, and analytical candidate who can think strategically
Excellent oral/written communication skills required
Reference Number: 40-25538
Salary Grade: 030
Employment Type: Exempt
Org: DM-Gene Therapy Program
Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Job Family: B-Executive/Managerial Administration