Research Associate

Charlottesville, VA
Apr 05, 2017
Institution Type
Four-Year Institution

Working Title: Research Associate

Position Type: Professional Research Staff

Department: Department of Pathology, Research

Location: Charlottesville

Posting Date: 02-02-2017

Posting Summary:
The Department of Pathology at the University of Virginia seeks a Postdoctoral Research Associate position in the laboratory of Dr. Hui Li. The broad areas of interest in Dr. Li's lab include: gene regulation, abnormal splicing, developmental biology, evolutional biology, and cancer.

Genes are considered the units of hereditary information, thus neither genes nor their encoded products are expected to mingle with each other unless in some disease situations. In cancer, a frequent mechanism that can produce gene fusions is chromosomal rearrangement. However, our work on RNA trans-splicing (Science 2008, Cancer Discovery 2013, NAR 2016, PNAS 2016) and cis-splicing between adjacent genes (cis-SAGe) (Cancer Discovery 2012, PLOS Genetics 2015) provide support for other mechanisms in generating fusion RNA at least in a few isolated cases. With RNA-sequencing, we are identifying hundreds of thousands of chimeric RNA that exceeds our wildest imagination. Ongoing projects are using bioinformatics, evolution biology, and many traditional approaches to study the characteristic, the function, the mechanism and the functional implication of these fusions in cancer and normal physiology.

To be considered for this position, applicants must have a recent PhD or MD/PhD degree with a strong background in bioinformatics, deep-sequencing analyses, and R language. The successful candidate will have excellent organizational, written and verbal communication skills.

Regarding the lab research directions, please visit:

To apply for this position, visit, and search posting number 0620268. Complete a candidate profile online; attach a cover letter, curriculum vitae, and contact information for three references. The position will remain open until filled.

For further information regarding the application process please contact Mary J. White via email at

The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.

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