Postdoctoral Associate – Biochemistry
A Post-Doctoral position is available immediately to develop and apply new methodologies in dissolution dynamic nuclear polarization to enable in vivo metabolic flux measurements. The focus of this project is to develop hardware, pulse sequences, and sample preparation strategies to maximize polarization enhancement for small molecule metabolites and to track them in vivo. Collaboration with users of the NHMFL facility wishing to apply the techniques as they are developed is especially encouraged.
Two DNP polarizers are available for this project--a custom-built 5 T / 1.2 K polarizer and an Oxford/GE Hypersense. These instruments are interfaced to preclinical 4.7 T / 30 cm and 11.1 T / 40 cm MRI/S systems as well as a 600 MHz NMR instrument with a 10 mm cryoprobe. Extensive infrastructure and staff support is available for the development of RF hardware, including DNP inserts and MR coils for particular applications, and development of new pulse sequences. The higher field instruments were recently upgraded with Bruker AVIII HD consoles operating with PV6.
$47,476 - $50,000
A Ph.D. and English language proficiency are required. Applicants should have a strong background in MRI/S methodologies. Experience with preclinical imaging and in vivo spectroscopy is necessary.
Familiarity with dissolution DNP techniques will be given preference. Also desirable would be familiarity with metabolism, modeling kinetics, and developing MR coils for tailored applications.
Special Instructions to Applicants:
Please submit current CV and 3 letters of recommendation along with online application.
Health Assessment Required: No