Research Associate

Location
Boulder, CO
Posted
Feb 21, 2017
Institution Type
Four-Year Institution



A joint position is available at the University of Colorado, Boulder. In addition to conducting research, this job provides additional managerial experience. Start date is flexible and interviews will take place on rolling basis.

The candidate would spend at least half of their time conducting research in the Hough Lab and the remainder as the manager of the small molecule NMR resource in the same building. The Hough Lab has an emphasis on biomolecular NMR, including that of tubulin and its binding partners. The small molecule NMR resource has a range of users including the Caruthers, Bowman, Yin, and Anseth research groups as well as a range of other users in Chemical and Biological Engineering, Biochemistry, and Chemistry.

In the Hough Lab, the candidate will work with two others on a collaborative project. Common methods in the lab include nuclear magnetic resonance spectroscopy (NMR), cloning new constructs, protein expression and purification, bacterial and T. thermophila cell culture, time-lapse microscopy, image processing, computational analysis of data.

The Hough Lab works at the interface of physics and biochemistry, looking at the role of intrinsically disordered domains in protein function (http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00507). This position is for a project to dissect the role of the C-terminal tail of tubulin on its function by NMR and other biophysical techniques. We use Tetrahymena thermophila as a source for tubulin, allowing us to complement MT bending, binding and other macromolecular measurements with high resolution information enabled by NMR. We will capitalize on the broad range of mutant strains with differential levels of tubulin modifications. The lab is in the new Jennie Smoly Caruthers Biotech Building on East Campus. The group website is part of the broader biophysics website: http://www.colorado.edu/physics-biophysics/

As the director of the small molecule NMR facility, the candidate would be responsible for maintenance of a Bruker Avance 400 MHz spectrometer, including routing cryogen fills and maintenance of the automated sample submission queues as well as expertise in sample preparation, experimental design. The candidate would facilitate equipment repair by Bruker - the instrument is covered with a service contract. The candidate would train all new users in operating the instrument and may assist with users seeking to perform more complicated experiments and analysis. The users perform research in fields ranging from organic synthetic chemistry, materials synthesis, chemical biology. The candidate will not be expected to be knowledgeable in all of these fields, but will be exposed to them.


Qualifications

Minimum qualifications: Ph.D. with experience in NMR.

Desired qualifications: Interested in working with a wide range of users and on collaborative projects. Responsible with effective communication skills. Knowledge of Bruker instruments and software.


Special Instructions to Applicants:The University of Colorado Boulder is committed to providing a safe and productive learning, living and working community. To achieve this goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and an EPLS (Excluded Parties List System) check. The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work.

The University of Colorado is an equal opportunity and affirmative action employer committed to assembling a diverse, broadly trained faculty and staff in compliance with applicable laws and in furtherance of its commitment to fostering an environment that welcomes and embraces diversity, the University of Colorado does not discriminate on the basis of race, color, creed, religion, national origin, sex (including pregnancy), disability, age, veteran status, sexual orientation, gender identity or expression, genetic information, political affiliation or political philosophy in its programs or activities, including employment, admissions, and educational programs. Inquiries may be directed to Boulder campus Title IX Coordinator by calling 303-492-2127.

Application Materials Required:Cover Letter, Resume/CV, List of References, Unofficial transcript(s), Additional Attachments - Refer to Application Materials Instructions Below

Application Materials Instructions:Interested candidates should submit as ONE PDF the following: 1. Cover letter (see details below) 2. CV including names and contact information of three references The cover letter should address the following: 1) What is your relevant experiences and expertise? 2) What is your current employment (if any), and why are you looking for a new position? 3) When are you available to start a new position? 4) What are your short and long-term professional goals? 5) Describe your ideal work environment and the workschedule you'd like to have . The final candidate will be required to provide a proof of degree as part of the final hiring dossier requirement. This position is eligible for medical, dental and life insurance, retirement benefits programs, and is eligible for monthly vacation and sick leave accruals. The University of Colorado Boulder conducts background checks on all final applicants being considered for employment, prior to the issuance of an offer letter.



Job Category: Faculty

Primary Location: Boulder

Department: B0001 -- Boulder Campus - 10763 - Biofrontiers Institute

Schedule: Full-time

Posting Date: Nov 29, 2016

Closing Date: Ongoing

Posting Contact Name: Loren Hough

Posting Contact Email: loren.hough@colorado.edu

Position Number: 00178343

PI96903806