RESEARCH INVESTIGATOR SR
Duties: Research at GTP requires knowledge of multiple scientific disciplines including molecular and cell biology, protein biochemistry, virology, immunology, bioinformatics, and biotechnology. Our major goals are to increase scientific knowledge in gene therapy field through the use of experiments, and help develop new life-saving treatments. Research performed at GTP ranges from basic research to development of platform technologies to development of the vector manufacturing methods to conducting pre-clinical research. Our research is carried out using cell and animal models.
The primary function of this position is to perform experiments in the laboratory setting, including molecular biology and biochemistry, as well as in vivo experiments in rodents and NHP. Secondary function of this position is to provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents. SRI is expected to contribute to writing manuscripts, preparing presentations, establishing collaborations.
The scientist will be responsible for design, optimization and implementation of complex experiments. The scientist will apply their expertise to develop and optimize novel therapeutic and prophylactic models in animals. Responsibilities include enzyme assay development and optimization, tissue culture work, and animal experimentation, including rodents and NHP. The SRI will perform laboratory experiments including isolating of the novel AAV vectors, vector design and cloning, and assay validations. This position offers the opportunity to interface broadly internally with diverse functional areas. The scientist will work independently to accomplish project goals within specified timelines, lead AAV technology discovery processes, and work cross functionally between multiple teams (Research, Vector Production, and Quality Control). The scientist will be responsible for writing/reviewing manuscripts, protocols, and SOPs.
The scientist may work in one of two general categories, described below:
1) Discovery research in development of next generation AAV vectors and/or genome editing. In each case, the scientist will be working in the setting of large interdisciplinary teams. S/he will function independently in the execution of the experiments but will need to work collaboratively with other team members.
2) Translational research projects. The scientist will work under the leadership of a Project Leader to help direct scientific aspects of a disease-based project team, many of which involve interactions with biopharmaceutical partners.
Qualifications: Minimum of 5 years of experience after the completion of the PhD degree in the field of molecular biology, biochemistry, enzymology, gene therapy, protein engineering, or related fields required. The successful candidate must thrive in a team environment, have excellent written and oral communication skills, ability to prioritize in a fast-paced environment, and proficiency with standard methods of data analyses
Reference Number: 40-24934
Salary Grade: RES
Employment Type: Exempt
Org: DM-Gene Therapy Program
Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Job Family: I-Technical/Professional Research