Philadelphia, Philadelphia County
Jun 24, 2016

Duties: This position will support and help drive laboratory research focusing on the therapeutic use of nucleoside modified mRNA, including vaccine development, delivery of therapeutic proteins, and generation of in vivo targeting of cells and tissues with CRISPR mediated gene editing. Duties will include basic and advanced molecular biology and cell culture techniques, animal studies using mice, rats, and rabbits with the potential to expand to other species, advanced surgical operations on animals including adrenalectomy, tracheotomy, and LN biopsy plus others to be added, advanced delivery of mRNA to animals including to the brain. Facility with bioinformatics tools such as Genome Browser and Ingenuity IPA software, as well as basic sequence analysis tools such as MacVector and DNAStar, will be expected. Individual will be expected to exhibit a very high degree of independence and take the lead on and manage a variety of projects. Individual will also be responsible for establishing new methods for the laboratory, training and overseeing junior lab members; will be expected to analyze and interpret data, contribute to manuscript and grant writing, prepare figures and presentations; will also be responsible for some lab managerial duties.

Qualifications: PhD in a biological science and a minimum of 5 to 7 years of relevant experience required. Laboratory experience in cell culture and molecular biology required; project management experience preferred; excellent organizational skills and attention to detail are required. Prior experience with nucleoside modified mRNA construction, purification, and therapeutic studies.

Reference Number: 40-23036

Salary Grade: RES

Employment Type: Exempt

Org: DM-Infectious Diseases

Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

Job Family: I-Technical/Professional Research

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