Posting Description: University of Colorado Denver Postdoc/Fellow Department of Pediatrics, Clinical Genetics & Metabolism Department of Pediatrics, Clinical Genetics & Metabolism has an opening for a Full time postdoctoral fellow to work in the Department of Pediatrics, Clinical Genetics & Metabolism at the Anschutz Medical Campus in Aurora. The Section of Clinical Genetics and Metabolism pursues clinical and basic research on numerous inherited conditions. Research involves the identification of the genetic basis of inherited disorders, both rare and common. In several rare genetic diseases, current research delineates the spectrum of mutations and how they can predict outcome. Translational research efforts are bringing these new findings to clinical care through our service laboratories. Mutagenesis studies review the impact of environmental variables on producing genetic changes. The University of Colorado Denver is seeking nominations and applications for the position of postdoctoral fellow. UC Denver is the premier research university in Colorado, serving more than 30,000 undergraduate, graduate and health professions students in Denver, Aurora and online and awarding nearly 4,000 degrees each year. The renowned researchers and award-winning faculty of UC Denver offer more than 100 degree programs through 13 colleges and schools. In 2008 the University was awarded more than $371 million in research grants and contracts. The new Anschutz Medical Campus includes over 5 million square feet of research, educational and clinical space on 227 acres. The Downtown Campus is located in one of America's most vibrant urban centers, just steps from the Denver Center for Performing Arts, the LoDo District and the state capitol. On both campuses, students, staff and faculty have access to a broad array of academic, professional, community, recreational and cultural opportunities. The University of Colorado Denver is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. Job Responsibilities: Down syndrome is caused by the increased expression, due to gene dosage, of genes contained on human chromosome 21. This project involves the study of molecular pathways that underlie normal learning and memory, and their perturbations in model systems relevant to intellectual disability in Down syndrome. The long term goal is the identification of therapeutics and targets for therapeutics that can prevent or decrease the cognitive deficits in Down syndrome. Critical tasks include (i) continued development of the Gene Function and Pathway Databases for human chromosome 21 and intellectual disability (http://gfuncpathdb.ucdenver.edu/iddrc/home.php), (ii) assisting bench scientists with analysis and presentation of protein profiling data generated by Reverse Phase Protein Arrays, and (iii) development/implementation of tools for visualization of protein networks. Relevant tasks include mining of functional genomics and proteomics databases and statistical analysis of protein expression patterns. Responsibilities also may include supervision of undergraduate and/or graduate students. This is a full time position in the laboratory of the PI at the Anschutz campus, in Aurora, CO.
Required Competencies/Knowledge, Skills, and Abilities: PhD degree in bioinformatics, or in systems biology/molecular biology with relevant experience computer programming (JAVA, R, php; SAS) and database management (MySQL). Must be self-motivated and able to work with moderate supervision. Must have good organizational skills, the ability to communicate well with bench scientists, and the curiosity and ability to handle and integrate complex datasets.
Desired Qualifications: Experience in functional genomics, use of pathway and protein interaction databases. Experience in statistics for microarray analysis.
Campus: Anschutz Medical Campus